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ea0056gp165 | Paediatrics, Developmental ' Female Reproduction | ECE2018

Early childhood BMI rise, the adiposity rebound, associates with PCOS diagnosis and obesity at ages 31 and 46 years – analysis of 46-year growth data from birth to adulthood in PCOS

Koivuaho Emilia , Laru Johanna , Jokelainen Jari , Ojaniemi Marja , Puukka Katri , Ruokonen Aimo , Kettunen Johannes , Tapanainen Juha , Franks Stephen , Jarvelin Marjo-Riitta , Morin-Papunen Laure , Sebert Sylvain , Piltonen Terhi

Background: The age at adiposity rebound (AR), at which BMI begins to rise after infancy around the age of 5 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has strong metabolic components, early growth patterns could reveal predisposition for PCOS. Thus, we aimed to investigate the associations of growth trajectories from birth to puberty with PCOS diagnosis,vbody composition and hyperandrogenism later in a...

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ea0057021 | Cardiovascular complications in pituitary gigantism (results of an international study) | BES2018

Cardiovascular complications in pituitary gigantism (results of an international study)

Liliya Rostomyan , Adrian Daly , Nalini Shah , Luciana A Naves , Anne Barlier , Marie-Lise Jaffrain-Rea , Philippe Emy , Sebastian Neggers , Lecumberri Santamaria Beatriz , Ian Holdaway , Thierry Brue , Gunter Stalla , Roberto Salvatori , Yves Bertherat Jerome , Dominique Maiter , Margaret Zacharin , Anurag Lila , Silvia Filipponi , Satinath Mukhopadhyay , Tapani Ebeling , Marja Ojaniemi , I McCormack Ann , Outi Kuismin , Anne-Lise Lecoq , Mona Sahnoun-Fathallah , Caroline Jung-Sievers , Elena Malchiodi , Liudmila Rozhinskaya , Elena Nazzari , Sachin Mittal , Elisa Verrua , Ekaterina Sorkina , Alexander Dreval , France Devuyst , Ismene Bilbao , Simona Auriemma Renata , Palacios Garcia Nuria , Irena Ilovaiskaya , Vyacheslav Pronin , Annamaria Colao , Diego Ferone , Anna Spada , Patrick Petrossians , Paolo Beck-Peccoz , A Stratakis Constantine , Philippe Chanson , Albert Beckers

Background: Cardiovascular disease is an important cause of morbidity/mortality in chronic GH hypersecretion.Aim: To evaluate cardiovascular system in a large series of patients with pituitary gigantism. Standard case report forms were used with height assessments related to local country norms. Results: 151pts (123 male) with GH-excess and abnormal growth velocity for age or final height >2SD over local norms had complete data on cardiac assessments...

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Endocrine Abstracts

Early childhood BMI rise, the adiposity rebound, associates with PCOS diagnosis and obesity at ages 31 and 46 years – analysis of 46-year growth data from birth to adulthood in PCOS

Cardiovascular complications in pituitary gigantism (results of an international study)

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